Treatment-Resistant Depression

More than 260 million people worldwide are affected by depression, a mental health disorder characterized by a persistently depressed mood or loss of interest in daily activities that can impact normal daily functioning, relationships and overall quality of life. Treatments range from selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs) and antidepressants. Along with behavioral therapy, these medications benefit between 40–70% of people suffering from depression. One third of patients do not benefit adequately from these treatments, which is often referred to as difficult-to-treat or treatment-resistant depression (TRD).

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