Uterine Fibroids

ELAGOLIX: AN INVESTIGATIONAL TREATMENT FOR UTERINE FIBROIDS

Gonadotropin-releasing hormone, or GnRH, is a peptide that stimulates the secretion of the pituitary hormones that are responsible for sex steroid production and normal reproductive function.

Elagolix, in combination with add-back therapy, is an orally active, non-peptide GnRH antagonist, being investigated for the treatment of uterine fibroids. It is believed that elagolix may be able to alter the level of pituitary GnRH suppression thereby titrating circulating hormone levels and may provide patients relief from the painful symptoms associated with uterine fibroids.

Pursuant to the collaboration between Neurocrine Biosciences and AbbVie, AbbVie is investigating elagolix for uterine fibroids. AbbVie is responsible for all development, marketing and commercialization costs.